The film tells the story of single mother “Kara” (Elizabeth Roberts) who moves from New York to the quiet countryside with her two children for a job opportunity she can’t afford to turn down. The family moves into their humble new guesthouse. Kara begins her work as a private nurse to “Walter,” (Bruce Davison) a man stricken with multiple sclerosis and an appraiser of rare antiquities with a secretive past.　　Her teenage son, Jesse, (Arman Darbo) is unhappy about this most of all. Losing his friends and moving to the middle of nowhere hasn’t made his job of looking after his little sister, “Cambria,” (Chloe Perrin) any easier.　　Doom precedes them. “Akiba,” (Treva Etienne) a shady international associate of Walter’s, brings with him a mysterious relic of ancient origin. “Kara” encounters run in with a local sheriff played by genre veteran actor Denise Crosby.　　All too quickly they discover the relic contains more than just legends. Inside, waits a terrifying creature born of ancient darkness and pure instinct…a pre-historic cave Spider unlike the modern world has ever seen.

在上一季的结尾，钢铁侠被留在了另个次元，这一次在没有钢铁侠的情况下，复仇者团队将会面临新的挑战，新的全新全异复仇者能否担负起拯救队员的责任呢？黑豹，幻世，惊奇队长，卡玛拉，蚁人，黄蜂女新组成的队伍能否担负起重任？